A palm-sized high-sensitivity near-infrared fluorescence imager for laparotomy surgery.
Identifieur interne : 000052 ( France/Analysis ); précédent : 000051; suivant : 000053A palm-sized high-sensitivity near-infrared fluorescence imager for laparotomy surgery.
Auteurs : Paul Dorval [France] ; Norman Mangeret [France] ; Stephanie Guillermet [France] ; Ihab Atallah [France] ; Christian Righini [France] ; Gabriele Barabino [France] ; Jean-Luc Coll [France] ; Philippe Rizo [France] ; Patrick Poulet [France]Source :
- Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) [ 1724-191X ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Chirurgie assistée par ordinateur (instrumentation), Colorants fluorescents (), Conception d'appareillage, Diagnostic par imagerie (), Diagnostic par imagerie (instrumentation), Femelle, Fibres optiques, Fluorescence, Humains, Hépatectomie, Laparotomie (), Laparotomie (instrumentation), Limite de détection, Lymphoedème (), Lymphoedème (anatomopathologie), Lymphoedème (diagnostic), Miniaturisation, Polymères (), Reproductibilité des résultats, Souris, Souris nude, Spectroscopie proche infrarouge (), Transplantation tumorale, Tumeurs colorectales (), Tumeurs colorectales (anatomopathologie), Tumeurs colorectales (diagnostic), Tumeurs de la tête et du cou (), Tumeurs de la tête et du cou (anatomopathologie), Tumeurs de la tête et du cou (diagnostic), Tumeurs du foie (), Tumeurs du foie (anatomopathologie), Tumeurs du foie (diagnostic), Vert indocyanine ().
- MESH :
- anatomopathologie : Lymphoedème, Tumeurs colorectales, Tumeurs de la tête et du cou, Tumeurs du foie.
- diagnostic : Lymphoedème, Tumeurs colorectales, Tumeurs de la tête et du cou, Tumeurs du foie.
- Animaux, Chirurgie assistée par ordinateur, Colorants fluorescents, Conception d'appareillage, Diagnostic par imagerie, Femelle, Fibres optiques, Fluorescence, Humains, Hépatectomie, Laparotomie, Limite de détection, Lymphoedème, Miniaturisation, Polymères, Reproductibilité des résultats, Souris, Souris nude, Spectroscopie proche infrarouge, Transplantation tumorale, Tumeurs colorectales, Tumeurs de la tête et du cou, Tumeurs du foie, Vert indocyanine.
English descriptors
- KwdEn :
- Animals, Colorectal Neoplasms (diagnosis), Colorectal Neoplasms (pathology), Colorectal Neoplasms (surgery), Diagnostic Imaging (instrumentation), Diagnostic Imaging (methods), Equipment Design, Female, Fluorescence, Fluorescent Dyes (chemistry), Head and Neck Neoplasms (diagnosis), Head and Neck Neoplasms (pathology), Head and Neck Neoplasms (surgery), Hepatectomy, Humans, Indocyanine Green (chemistry), Laparotomy (instrumentation), Laparotomy (methods), Limit of Detection, Liver Neoplasms (diagnosis), Liver Neoplasms (pathology), Liver Neoplasms (surgery), Lymphedema (diagnosis), Lymphedema (pathology), Lymphedema (surgery), Mice, Mice, Nude, Miniaturization, Neoplasm Transplantation, Optical Fibers, Polymers (chemistry), Reproducibility of Results, Spectroscopy, Near-Infrared (methods), Surgery, Computer-Assisted (instrumentation).
- MESH :
- chemical , chemistry : Fluorescent Dyes, Indocyanine Green, Polymers.
- diagnosis : Colorectal Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Lymphedema.
- instrumentation : Diagnostic Imaging, Laparotomy, Surgery, Computer-Assisted.
- methods : Diagnostic Imaging, Laparotomy, Spectroscopy, Near-Infrared.
- pathology : Colorectal Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Lymphedema.
- surgery : Colorectal Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Lymphedema.
- Animals, Equipment Design, Female, Fluorescence, Hepatectomy, Humans, Limit of Detection, Mice, Mice, Nude, Miniaturization, Neoplasm Transplantation, Optical Fibers, Reproducibility of Results.
Abstract
In laparotomy surgery guided by near-infrared fluorescence imaging, the access to the field of operation is limited by the illumination and/or the imaging field. The side of cavities or organs such as the liver or the heart cannot be examined with the systems available on the market, which are too large and too heavy. In this article, we describe and evaluate a palm sized probe, whose properties, weight, size and sensitivity are adapted for guiding laparotomy surgery. Different experiments have been performed to determine its main characteristics, both on the illumination and imaging sides. The device has been tested for fluorescent molecular probe imaging in preclinical procedures, to prove its ability to be used in cancer nodule detection during surgery. This system is now CE certified for clinical procedures and Indocyanine Green imaging has been performed during clinical investigations: lymphedema and surgical resection of liver metastases of colorectal cancers.
DOI: 10.1016/j.ejmp.2015.11.006
PubMed: 26654116
Affiliations:
- France
- Alsace (région administrative), Auvergne-Rhône-Alpes, Grand Est, Rhône-Alpes
- Grenoble, Illkirch, Saint-Etienne
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pubmed:26654116Le document en format XML
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Electronic address: philippe.rizo@fluoptics.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Fluoptics, 38040 Grenoble, France; CEA-LETI, Minatec, 38054 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Poulet, Patrick" sort="Poulet, Patrick" uniqKey="Poulet P" first="Patrick" last="Poulet">Patrick Poulet</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie, UMR 7357, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg/CNRS, 67412 Illkirch, France. 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Electronic address: paul.dorval@live.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie, UMR 7357, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg/CNRS, 67412 Illkirch, France; Fluoptics, 38040 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Mangeret, Norman" sort="Mangeret, Norman" uniqKey="Mangeret N" first="Norman" last="Mangeret">Norman Mangeret</name><affiliation wicri:level="3"><nlm:affiliation>Fluoptics, 38040 Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Fluoptics, 38040 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Guillermet, Stephanie" sort="Guillermet, Stephanie" uniqKey="Guillermet S" first="Stephanie" last="Guillermet">Stephanie Guillermet</name><affiliation wicri:level="3"><nlm:affiliation>Fluoptics, 38040 Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Fluoptics, 38040 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Atallah, Ihab" sort="Atallah, Ihab" uniqKey="Atallah I" first="Ihab" last="Atallah">Ihab Atallah</name><affiliation wicri:level="3"><nlm:affiliation>Institut Albert Bonniot, U-823, Université Joseph Fourier/INSERM, 38000 Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Albert Bonniot, U-823, Université Joseph Fourier/INSERM, 38000 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Righini, Christian" sort="Righini, Christian" uniqKey="Righini C" first="Christian" last="Righini">Christian Righini</name><affiliation wicri:level="3"><nlm:affiliation>Institut Albert Bonniot, U-823, Université Joseph Fourier/INSERM, 38000 Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Albert Bonniot, U-823, Université Joseph Fourier/INSERM, 38000 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Barabino, Gabriele" sort="Barabino, Gabriele" uniqKey="Barabino G" first="Gabriele" last="Barabino">Gabriele Barabino</name><affiliation wicri:level="3"><nlm:affiliation>Centre Hospilato-Universitaire de Saint-Etienne, 42000 Saint-Etienne, France. Electronic address: gabriele.barabino@chu-st-etienne.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospilato-Universitaire de Saint-Etienne, 42000 Saint-Etienne</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Etienne</settlement></placeName></affiliation></author><author><name sortKey="Coll, Jean Luc" sort="Coll, Jean Luc" uniqKey="Coll J" first="Jean-Luc" last="Coll">Jean-Luc Coll</name><affiliation wicri:level="3"><nlm:affiliation>Institut Albert Bonniot, U-823, Université Joseph Fourier/INSERM, 38000 Grenoble, France. Electronic address: jean-luc.coll@ujf-grenoble.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Albert Bonniot, U-823, Université Joseph Fourier/INSERM, 38000 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Rizo, Philippe" sort="Rizo, Philippe" uniqKey="Rizo P" first="Philippe" last="Rizo">Philippe Rizo</name><affiliation wicri:level="3"><nlm:affiliation>Fluoptics, 38040 Grenoble, France; CEA-LETI, Minatec, 38054 Grenoble, France. Electronic address: philippe.rizo@fluoptics.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Fluoptics, 38040 Grenoble, France; CEA-LETI, Minatec, 38054 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Poulet, Patrick" sort="Poulet, Patrick" uniqKey="Poulet P" first="Patrick" last="Poulet">Patrick Poulet</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie, UMR 7357, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg/CNRS, 67412 Illkirch, France. Electronic address: p.poulet@unistra.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie, UMR 7357, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg/CNRS, 67412 Illkirch</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Illkirch</settlement></placeName></affiliation></author></analytic><series><title level="j">Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)</title><idno type="eISSN">1724-191X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Colorectal Neoplasms (diagnosis)</term><term>Colorectal Neoplasms (pathology)</term><term>Colorectal Neoplasms (surgery)</term><term>Diagnostic Imaging (instrumentation)</term><term>Diagnostic Imaging (methods)</term><term>Equipment Design</term><term>Female</term><term>Fluorescence</term><term>Fluorescent Dyes (chemistry)</term><term>Head and Neck Neoplasms (diagnosis)</term><term>Head and Neck Neoplasms (pathology)</term><term>Head and Neck Neoplasms (surgery)</term><term>Hepatectomy</term><term>Humans</term><term>Indocyanine Green (chemistry)</term><term>Laparotomy (instrumentation)</term><term>Laparotomy (methods)</term><term>Limit of Detection</term><term>Liver Neoplasms (diagnosis)</term><term>Liver Neoplasms (pathology)</term><term>Liver Neoplasms (surgery)</term><term>Lymphedema (diagnosis)</term><term>Lymphedema (pathology)</term><term>Lymphedema (surgery)</term><term>Mice</term><term>Mice, Nude</term><term>Miniaturization</term><term>Neoplasm Transplantation</term><term>Optical Fibers</term><term>Polymers (chemistry)</term><term>Reproducibility of Results</term><term>Spectroscopy, Near-Infrared (methods)</term><term>Surgery, Computer-Assisted (instrumentation)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chirurgie assistée par ordinateur (instrumentation)</term><term>Colorants fluorescents ()</term><term>Conception d'appareillage</term><term>Diagnostic par imagerie ()</term><term>Diagnostic par imagerie (instrumentation)</term><term>Femelle</term><term>Fibres optiques</term><term>Fluorescence</term><term>Humains</term><term>Hépatectomie</term><term>Laparotomie ()</term><term>Laparotomie (instrumentation)</term><term>Limite de détection</term><term>Lymphoedème ()</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (diagnostic)</term><term>Miniaturisation</term><term>Polymères ()</term><term>Reproductibilité des résultats</term><term>Souris</term><term>Souris nude</term><term>Spectroscopie proche infrarouge ()</term><term>Transplantation tumorale</term><term>Tumeurs colorectales ()</term><term>Tumeurs colorectales (anatomopathologie)</term><term>Tumeurs colorectales (diagnostic)</term><term>Tumeurs de la tête et du cou ()</term><term>Tumeurs de la tête et du cou (anatomopathologie)</term><term>Tumeurs de la tête et du cou (diagnostic)</term><term>Tumeurs du foie ()</term><term>Tumeurs du foie (anatomopathologie)</term><term>Tumeurs du foie (diagnostic)</term><term>Vert indocyanine ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Fluorescent Dyes</term><term>Indocyanine Green</term><term>Polymers</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Tumeurs colorectales</term><term>Tumeurs de la tête et du cou</term><term>Tumeurs du foie</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Colorectal Neoplasms</term><term>Head and Neck Neoplasms</term><term>Liver Neoplasms</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Lymphoedème</term><term>Tumeurs colorectales</term><term>Tumeurs de la tête et du cou</term><term>Tumeurs du foie</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Diagnostic Imaging</term><term>Laparotomy</term><term>Surgery, Computer-Assisted</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diagnostic Imaging</term><term>Laparotomy</term><term>Spectroscopy, Near-Infrared</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colorectal Neoplasms</term><term>Head and Neck Neoplasms</term><term>Liver Neoplasms</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Colorectal Neoplasms</term><term>Head and Neck Neoplasms</term><term>Liver Neoplasms</term><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Equipment Design</term><term>Female</term><term>Fluorescence</term><term>Hepatectomy</term><term>Humans</term><term>Limit of Detection</term><term>Mice</term><term>Mice, Nude</term><term>Miniaturization</term><term>Neoplasm Transplantation</term><term>Optical Fibers</term><term>Reproducibility of Results</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Chirurgie assistée par ordinateur</term><term>Colorants fluorescents</term><term>Conception d'appareillage</term><term>Diagnostic par imagerie</term><term>Femelle</term><term>Fibres optiques</term><term>Fluorescence</term><term>Humains</term><term>Hépatectomie</term><term>Laparotomie</term><term>Limite de détection</term><term>Lymphoedème</term><term>Miniaturisation</term><term>Polymères</term><term>Reproductibilité des résultats</term><term>Souris</term><term>Souris nude</term><term>Spectroscopie proche infrarouge</term><term>Transplantation tumorale</term><term>Tumeurs colorectales</term><term>Tumeurs de la tête et du cou</term><term>Tumeurs du foie</term><term>Vert indocyanine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In laparotomy surgery guided by near-infrared fluorescence imaging, the access to the field of operation is limited by the illumination and/or the imaging field. The side of cavities or organs such as the liver or the heart cannot be examined with the systems available on the market, which are too large and too heavy. In this article, we describe and evaluate a palm sized probe, whose properties, weight, size and sensitivity are adapted for guiding laparotomy surgery. Different experiments have been performed to determine its main characteristics, both on the illumination and imaging sides. The device has been tested for fluorescent molecular probe imaging in preclinical procedures, to prove its ability to be used in cancer nodule detection during surgery. This system is now CE certified for clinical procedures and Indocyanine Green imaging has been performed during clinical investigations: lymphedema and surgical resection of liver metastases of colorectal cancers.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Alsace (région administrative)</li><li>Auvergne-Rhône-Alpes</li><li>Grand Est</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li><li>Illkirch</li><li>Saint-Etienne</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Dorval, Paul" sort="Dorval, Paul" uniqKey="Dorval P" first="Paul" last="Dorval">Paul Dorval</name></region><name sortKey="Atallah, Ihab" sort="Atallah, Ihab" uniqKey="Atallah I" first="Ihab" last="Atallah">Ihab Atallah</name><name sortKey="Barabino, Gabriele" sort="Barabino, Gabriele" uniqKey="Barabino G" first="Gabriele" last="Barabino">Gabriele Barabino</name><name sortKey="Coll, Jean Luc" sort="Coll, Jean Luc" uniqKey="Coll J" first="Jean-Luc" last="Coll">Jean-Luc Coll</name><name sortKey="Guillermet, Stephanie" sort="Guillermet, Stephanie" uniqKey="Guillermet S" first="Stephanie" last="Guillermet">Stephanie Guillermet</name><name sortKey="Mangeret, Norman" sort="Mangeret, Norman" uniqKey="Mangeret N" first="Norman" last="Mangeret">Norman Mangeret</name><name sortKey="Poulet, Patrick" sort="Poulet, Patrick" uniqKey="Poulet P" first="Patrick" last="Poulet">Patrick Poulet</name><name sortKey="Righini, Christian" sort="Righini, Christian" uniqKey="Righini C" first="Christian" last="Righini">Christian Righini</name><name sortKey="Rizo, Philippe" sort="Rizo, Philippe" uniqKey="Rizo P" first="Philippe" last="Rizo">Philippe Rizo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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